Max and Helen adjust to sharing their lives and their problems, including the challenge of Helen's mother; Bloom and Reynolds treat a family after their horrific car accident lands them in the ED; Iggy and Trevor reach a new understanding.
Max creates chaos when he volunteers New Amsterdam to take over for a short-staffed neighboring hospital; Frome has a crisis of conscience about the funding for a hospital garden; an eager resident learns a secret about Bloom.
The recipient of Max's sister's heart arrives at New Amsterdam just as Max convinces Sharpe to take a risk on his course of treatment; Frome works to help a trans patient; Bloom grapples with a difficult conversation.
Max continues to work to solve underlying problems within the hospital despite his struggles with treatment; Reynolds makes the choice to do a costly surgery to determine an elusive diagnosis; Bloom must face her personal demons head-on.
Max is forced to face the heartbreaking consequences of one of his policies; Bloom comes to a startling realization about Iggy.