Meredith furiously works to save the life of a paramedic trapped in an ambulance; Lexie holds a patient's life in her hands; Derek must rely on a nurse's help to save a patient; Bailey struggles to balance her personal life with work.
An ambulance crash endangers the lives of the paramedics involved; Bailey treats a patient who refuses her help; Ava returns for Alex and meets his other girlfriend.
Things have changed in the five years since Katherine shot her ex-husband: Katherine is jealous as her business partner Bree is on the verge of publishing her own cookbook; Susan tries to hide her new relationship; Gaby doubts her abilities as a mom.
Lynette discovers the softer side of her son Porter; Gaby tries to downplay her decline in social stature; the men in Susan's life meet; Bree feels the pressure of balancing motherhood and a career.
Danielle, Bree's estranged daughter, returns to Wisteria Lane and is overwhelmed with criticism; Susan and Gaby end up in a catfight; Lynette is annoyed when she finds out that Tom and Dave have formed a garage band.
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