A catastrophe rocks Seattle, forcing the doctors of Grey Sloane Memorial Hospital to set their emotions aside.
Betty and Henry make a date to see "Wicked," but things do not go as planned; Daniel woos an important advertiser (Marlo Thomas) with a penchant for younger men.
Still missing Henry, Betty fights her attraction to Gio; Hilda tries to get Coach Diaz to notice her; Amanda agrees to do a reality show with her father, rock legend Gene Simmons; Wilhelmina makes a triumphant return to Mode.
Earl flies a former foreign-exchange student, whom he used to torture, to America to show him all of the great things the country has to offer.