Izzie ponders whether to have a risky procedure; a patient prompts Owen to reassess his place at Seattle Grace; George has stunning news for Bailey; the doctors of Seattle Grace band together to save the victim of a traffic accident.
Jane enlists his colleagues in a dangerous sting operation to catch a deadly team of art thieves. Meanwhile, sparks fly between Lisbon and an agent from the FBI's art squad – Marcus Pike (guest star PEDRO PASCAL).
The BAU looks for a suspect and a motive when victims are found in truck stop restrooms in the South.
Addison tries to fix the financial issues at Oceanside Wellness, only to put the practice in danger; Violet must choose whether to break the law to help a friend; Maya hopes her parents are rekindling their relationship for good.
The team pursues a couple reminiscent of Bonnie and Clyde when the duo goes on the run to hunt for a set of rare chess pieces that is worth millions; Darryl's ex-girlfriend visits with his young son.