Meredith and Derek get one last shot at success in their clinical trial; the surgeons work together to free a boy from a block of cement; Izzie helps Alex care for Rebecca; Lexie uncovers critical information about George's status as an intern.
Melinda delves into the complex world of high school romance and gossip as she tries to uncover the reason behind various hauntings at Ned's new school.
While in a Panamanian prison, Michael must find a mysterious fellow-inmate hiding in the sewer system; Lincoln searches for Sara; troubling news about L.J.
Determined to speak with Sara, Michael enlists T-Bag's help to get to the only phone in Sona; Lincoln tries a daring rescue; Whistler comes clean to Michael; Bellick makes an enemy while trying to get back on his feet.
Michael seeks revenge against Whistler and Gretchen and uncovers unbelievable news; Lincoln and Michael are reunited with the gang and get an offer from a Homeland Security agent; Mahone experiences a devastating loss; T-Bag is deserted.
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