Phil and Claire panic when an obnoxious couple looks at the house for sale next door; Jay learns Manny's girlfriend is the granddaughter of a business rival -- after forbidding Manny to see her; Cam and Mitch are scared of Lily's teacher (Tyne Daly).
Derek's mother makes a surprise visit and meets Meredith for the first time; Mark tries to hide his relationship with Lexie; Cristina and Owen try to go on their first date.
Amelia and Link travel to New York to operate on a patient who has a severe spinal deformity, but they're in for more than they bargained for when Nancy Shepherd invites them to dinner at her home.
Bonnie has success creating a line of mocktails for Adam's bar; Jill finds herself attracted to Bonnie's therapist.
President Elizabeth McCord kicks off a new landmark political initiative with help from members of the World Cup Champion U.S. Women's Soccer team, while Flo Avery (Cicely Tyson), who was born the day women were granted the right to vote, looks on. Opposing the initiative is Senator Amy Ross (Tyne Daley) from Ohio. Also, the McCords overcome last-minute obstacles to pull off a spectacular family celebration with a reunion of familiar faces, that includes a performance by Peter Frampton.
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