Just as she's about to embark on a tour, comic Amy Schumer learns she's pregnant with her first child; Amy and her husband, Chris, begin to grow concerned as her second trimester finds her throwing up daily; things take a scary turn.

After checking into the ER, Amy receives a diagnosis that gives her more insight into her hellish pregnancy, but also requires her to reschedule the taping of her special; Amy and Chris notice a concerning pattern of communication issues.

Twenty-three weeks pregnant, Amy takes the stage in Chicago to film her special; after her set, she and Chris shift their focus to parenthood, but they learn of another possible complication; at long last, Amy gives birth to her son, Gene.