Lissa, a royal vampire, and her best friend and protector, Rose, navigate romance, class politics and ancient magic at their boarding school St. Vladimir's Academy. As Rose trains to be a guardian, a mysterious bond develops between the two friends and they must work together to decipher it, all while facing threats like the bloodthirsty and undead strigoi. The series is the second adaptation of the novel series by Richelle Mead, the first being the 2014 film of the same name, and serves as a reboot.