John (David Bowie) is the lover of the gorgeous immortal vampire Miriam (Catherine Deneuve), and he's been led to believe that he'll live forever, too. Unfortunately, he quickly deteriorates into a horrible living death, and Miriam seeks a new companion. She soon sets her sights on Sarah (Susan Sarandon), a lovely young scientist, who quickly falls under Miriam's spell. However, Sarah doesn't warm up to the concept of vampirism easily, leading to conflict with Miriam.