Jack Yang

Zooey Deschanel stars as Jess Day, a young woman who, after discovering her long-term boyfriend is cheating on her, moves into a loft apartment with three male roommates – prickly bartender Nick, womanizer Schmidt and intense personal trainer Coach. In the opener, the guys try to help Jess get back on her feet and into the dating world.

The Thanksgiving holiday is more difficult for the interns and residents than any of them is willing to admit, as Izzie plans a big dinner at Meredith's -- but it remains to be seen who among the invited guests will actually show up. Meanwhile, George endures the O'Malley tradition of hunting turkeys with his less-than-sophisticated family, and Meredith treats a patient who's been in a vegetative state for 16 years.

Abby's parents come to town with an unusual request; at the insistence of her daughter, Abby reaches out to Becca for a meeting; Jo goes on an online dating binge; Phoebe goes on a date with her professor.

The men of Seattle Grace go on a camping trip together, Addison and Callie must team up to work on a patient, Meredith assists Sloan with a procedure unlike any she has experienced, and, suspicious of her recent actions at the hospital, Bailey confronts Cristina.

The interns take the biggest test of their careers, their first-year medical exams, as the residents attend to three injured mountain climbers. Meanwhile Callie's suspicions of George and Izzie grow, and Cristina struggles to write her wedding vows.

Cristina and Burke's wedding day arrives - along with the interns' first exam results - and a successor to the Chief is named, as Callie and George make a big decision about their relationship.