Meredith Grey and four other first-year surgical interns try to balance life and work at Seattle Grace Hospital.
Cristina proves to be a difficult patient as she continues to recover; Meredith's mother keeps the hospital staff running in circles; Dr. Shepherd's involvement in the case of a cystic fibrosis patient could delay her departure.
When Ted attends his mother's wedding, he is disturbed by her overly affectionate relationship with her fiance.
Burke and Yang disagree on how to treat a young boy who does not seem to want a needed heart-transplant.
Meredith's premonition of having a bad day is realized when a medical case arrives threatening the lives of everyone in the OR.