Chris O'Donnell

The doctors of Seattle Grace help Izzie cope with the loss of her fiancé, Denny, and her decision to quit the internship program. Meredith must decide what the future holds after her hospital liaison with Derek. The Chief is confronted by his wife, Adele, after spending the night in his office, and George seeks relationship advice from a surprising source, on the season premiere of "Grey's Anatomy."

Finn gives a health update on Doc, Meredith is assigned to work with Callie for the day while George gets paired with Derek, and Burke and Izzie continue to try to find a heart for Denny.

Richard goes into interrogation mode about a patient’s condition, Callie confronts George about his feelings for her, and Meredith and Derek meet about Doc.

Cristina tries to help Preston cope with his hand tremor, Izzie attempts to return to the hospital for the first time since she quit the program, Alex deals with a patient who has a long history of injuries, and George and Callie's relationship moves forward.

George begins to overstay his welcome at Burke's apartment; Meredith learns a secret about her father; Bailey worries her colleagues will not treat her the same now that she's a mother; and Alex gets a lesson in bedside manners.