A Princeton student who is graduating suffers a seizure while partying at a frat house, and House's parents drop by to see their son.
House is on the way to the funeral of his father but en-route, he and the team must help a Chinese girl who has collapsed under mysterious circumstances.
In the emotional series finale, directed by series creator and executive producer David Shore, treating a drug addict patient (guest star James LeGros, "Mildred Pierce") results in House examining his life, his future and his own personal demons.
House and the team battle to save a successful, independent blind man (guest star Michael B. Jordan) who is struck down by a mysterious illness, just prior to him asking for his girlfriend’s hand in marriage. Meanwhile, House’s mother (guest star Diane Baker) unexpectedly arrives at Princeton Plainsboro to inform him of her new beau (guest star Billy Connolly).
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