It's National HIV Testing Day and Max has offered free care to all HIV+ patients. Bloom and Reynolds butt heads over their opposing bedside manners. Iggy eagerly awaits the return of a friend. Sharpe discovers that she may need more hands on with her niece.
Max works to find a new normal three months after the accident and the birth of his daughter. Kapoor grapples with the stigma of aging. Iggy has a successful day that inspires a life-changing idea. Reynolds deals with an unreliable new intern.
Max and Sharpe wake up to a new, more personal dynamic. Iggy calls upon an old contact to help with an explosive situation. Bloom begins a tricky dynamic with her new ED residents and Reynolds finds himself in an awkward position with Dr. Baptiste and Dr. Lyn Malvo.
Sharpe has an important realisation that will affect her career. Meanwhile, Max and Reynolds take on uncharted waters when a young patient comes to New Amsterdam with symptoms of a heart attack.
With the hospital on lockdown after the Rikers patients' escape, Sharpe and Max find themselves in a situation that could cost them their lives. Meanwhile, Bloom must put aside her pain to help a patient in need, while Iggy is forced to face the issues in his marriage.