Max and his staff work together to keep the patients safe, when a record-breaking blizzard hits New York. They are determined even to brave the dreadful storm themselves to save the people under their care.
The doctors try to save an NYPD who was hit by a car while on the job. Meanwhile, Kapoor and Iggy care for a patient struggling with issues from a previous surgery.
When Sharpe has a case that hits close to home, she and Max team up to make things right for the patient; Iggy and Bloom are forced to make a tough call on a unique situation.
When a group of women on a retreat end up in the ED, Max gets some troubling information that could put a patient in jeopardy; Sharpe and Kapoor work together to mend fences between two feuding sisters.
The recipient of Max's sister's heart arrives at New Amsterdam just as Max convinces Sharpe to take a risk on his course of treatment. Frome works to help a trans patient. Bloom grapples with a difficult conversation.
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