With the wormhole closed, Sisko struggles for a way to contact the Bajoran prophets; Kira opens a Romulan military hospital; Dax's new host arrives in his hour of need.
Sisko's quest for the Bajoran Orb leads him to the truth of his existence; Kira sets a blockade against the Romulans; Worf destroys a Dominion shipyard to prepare a place in Sto-vo-kor for Jadzia Dax.
Despite the warning of the Prophets, Sisko leads an invasion of Cardassia, unaware that Gul Dukat has an ungodly plan.
A plan to use a captured Jem'Hadar ship to sabotage a ketracel-white storage facility leaves Sisko and crew without warp drive and 17 years away from the nearest starbase.
Destiny threatens Sisko's union; Gul Dukat involves himself in Kai Winn's vision; Breen soldiers take Ezri and Worf to the Jem'Hadar.