Sharpe has an important realization that will affect her career; Max and Reynolds take on uncharted waters when a young patient comes to New Amsterdam with symptoms of a heart attack.
With the hospital on lockdown after the Rikers patients escape, Sharpe and Max find themselves in a situation that could cost them their lives; Bloom must put aside her pain to help a patient; Iggy is forced to face his marriage's issues.
Max works to find a new normal three months after the accident and the birth of his daughter; Kapoor grapples with the stigma of aging; Iggy has a successful day that inspires a life-changing idea; Reynolds deals with an unreliable new intern.
Tommy must decide how to deploy the LAPD's resources when a climate change protest brings riots and a bomb threat at the same time as a mudslide shuts down a major freeway.
It's National HIV Testing Day and Max has offered free care to all HIV+ patients who come to New Amsterdam; Bloom and Reynolds butt heads over their opposing bedside manners; Iggy eagerly awaits the return of a friend; Sharpe makes a discovery.
