An unknown subject in Phoenix abducts people and deprives them of sleep; Garcia and Hotch deal with a threat from hit men.
With help from Lance Hunter, nothing will stop Fitz from finding the lost team as his secret journey is revealed.
Daisy's future as the destroyer of worlds could take a critical change.
Coulson is forced to team up with surprising allies to save the world, while the S.H.I.E.L.D. team attempts to track down and rescue him.
The team must find a way to stop Ruby before the prophesied chain reaction that can destroy Earth is put into motion.