The brother of death-row inmate Lincoln Burrows intentionally gets himself incarcerated, then plans to use his skills as a structural engineer to free him.
The tables are turned when one of the group's relentless pursuers becomes the pursued.
Michael, Lincoln and their fellow inmates run for their lives and their freedom, with Bellick in pursuit; Veronica races to Montana.
Sara considers whether she should help Michael with his plan, Michael betrays Warden Pope, and Veronica finds evidence that points her to Montana, but realizes that her closest ally may actually be her greatest enemy.
Michael must move up the breakout timetable; Michael looks to Sarah for help; Veronica finds her life in jeopardy from an unlikely character.
