Philip (Steve Martin) manages a suicide-prevention hotline called Lifesavers, assisted by Mrs. Munchnik (Madeline Kahn) and Catherine (Rita Wilson). On Christmas Eve, Philip learns that their landlord (Garry Shandling) is evicting them from their office. Amid all this unrest, Catherine proclaims her love for Philip. And when a transvestite (Liev Schreiber) and a pregnant woman (Juliette Lewis) enter into the equation, things get even more interesting.