Ramon De Ocampo

27 years after a virus wipes out most of humanity, scientists send a man (James Cole) back to 2015 to stop the plague from ever happening. Cole's only lead is a virologist (Dr. Cassandra Railly), who knows the dangerous source of the outbreak.

The attendings are extra-attentive to a patient, who is the chairman of the hospital board; Cristina helps Burke plan the wedding.

Forces come to a head when Ramse takes measures to protect his newfound family, leaving Cole to deal with the fallout.

Jennifer Goines forms The Hyenas to take on the 12 Monkeys' organization and with the help of Cole, they discover a plan to acquire the virus.

A young mathematician is shot with a 200-year-old bullet, inspiring wild theories by Castle about a time-traveling murderer.

Fresh out of jail, Sam Crow reunites with family, confronts new Charming law enforcement, and shifts business alliances.