Over a busy weekend in Manchester, North West Ambulance Service paramedics Andrea and Glynn attend an RTC; Debbie and Shaun try to persuade a homeless man to go to the hospital.

A distressed mother calls for help for her 19-year-old daughter who is self-harming; advanced paramedic Luke is dispatched to a 9-year-old boy feared to be in cardiac arrest; Gina and Jimmy treat a 12-year-old who has had an accident at judo.

A suspected terror incident requires a large-scale response and brings back memories of the Manchester Arena attack for paramedics; the team is kept busy dealing with a repeat caller who moves around Manchester's canals on his barge.

Call handler Joe is starting his first night shift, and after 12 weeks of training, he is thrown straight into the deep end with a difficult call; HEMS members Simon and Laura are dispatched to a category one emergency.

A panicked caller needs help for a friend who has given birth in a hotel room despite not knowing she was pregnant; crewmates Danny and Ben are dispatched to a patient who is lying in the street after taking a cocktail of drugs.

Performance manager Saj is concerned that he does not have enough ambulances for all the patients needing them, and the situation worsens when a call is received from the fire service.