Sam and Dean investigate some recent vampire kills and are surprised to learn that teenage hunter (and fan favorite) Krissy Chambers (guest star Madison McLaughlin) is involved. They find Krissy and learn her father was killed and trhat she’s been taken in by a man named Victor (guest star Adrian Hough) – who has taken in a group of orphan kids to teach them how to hunt. Victor is helping the teenagers find the vampires who took their parents so they can get revenge. While Sam is intrigued by Victor’s method of giving the teenagers a home life as well as a hunting life, Dean is suspicious of Victor’s motives.
With Rumplestiltskin as her slave, Zelena challenges Regina to a fight to the death and shocks the Evil queen with the reveal of their familial connection, and the town lays Neal to rest.
Hades asks Zelena to heal his heart with true love's kiss, so they can leave the Underworld and trap the heroes there forever; Regina finds out about Hades' plan and enlists Cora to help find a way to separate Hades from Zelena.
Lex is using a boy named Tobias, who was once blinded by the meteor shower and also has the ability to identify other meteor freaks. Lex wants Tobias to help him locate other people with special powers so that he can perform experiments on them. Lana learns of Tobias and is fearful that he will name Clark as a freak, so she offers him a cornea transplant to keep him quiet. However, Tobias has some surprising news.
While the Division deals with a murderer who uses a poison that can't possibly exist, Agents Farnsworth and Dunham from the Other Side come to pay them a visit.
