After being drugged and kidnapped by Murdoc, MacGyver manages to escape using a needle and his teeth, and he must help the team stop the assassin from harming his next victim.
Matty and the team reunite with bounty hunting family The Coltons to catch a former government worker who's run off with some big secrets.
The team strives to recover the body of a pilot whose plane went down while testing an experimental laser mapping system. Meanwhile, Riley tries to identify the hacker who fooled a SWAT team.