Curtis Harris

Izzie returns to work while the Seattle Grace residents fear possible layoffs; Bailey and Alex's difficult case is further complicated by her schizophrenic son.

Colonel Broyles is hit hard when a serial kidnapper `Over There' strikes again. Meanwhile, Olivia needs Henry's help as her fight to return home rages on.

While Walter takes a trip to the Alternate Universe to assist in an investigation that has ties to both worlds, David Robert Jones reveals his next target.

Mark, Demetri and Wedeck try to find a connection between Janis's attack and a separate assault. Meanwhile, as Halloween approaches, Olivia confronts Mark about his flashforward, and Demetri and Gough track down a clue that was foreshadowed in Mark's vision. Elsewhere, Lloyd's son Dylan goes missing from the hospital, and the elusive Simon makes contact with a reluctant acquaintance.