Phillip and Elizabeth Jennings seem like any other American married couple, but they are actually highly trained Soviet spies, who must kidnap a high-ranking defector and return him to Russia.
Carol receives a second chance at life when a new heart becomes available; Choi and Archer find themselves in hot water with an old patient; Halstead faces the consequences of the stolen trial medication.
Third-year med students begin their rotation in the ED, and Maggie keeps a careful eye on one of them; Manning, whose mom's health takes another decline, tries to cover up how she broke the rules to treat her.
US President Ronald Reagan has been shot. Elizabeth and Phillip are up against the clock and the FBI in trying to find out who is responsible and whether they need protecting.
Phillip and Elizabeth shock their children when they announce they are separating. Meanwhile, Gaad orders an unauthorised mission to grab a KGB agent after Amador goes missing, with grisly consequences.