When the dead body of a sailor is found in an abandoned part of town, all the evidence seems to show that the person died from an unintentional drug overdose. However, when the team dig deeper, it turns out to be murder.
Fitz and the team ask an Asgardian for help unlocking the secrets of the monolith that swallowed Simmons. Meanwhile, May comes to a crossroads.
S.H.I.E.L.D. puts everything on the line to survive a war that blurs the line between friend and foe. Coulson and his team will be forced to make shocking sacrifices that will leave their relationships and their world changed forever.
Coulson and the team search for the Inhuman who is killing other Inhumans; May worries Hunter's mission to bring down Ward is becoming too personal.
Mack, Daisy and Coulson race against time to keep Lincoln safe; Hunter will do whatever it takes to get revenge.