Max creates chaos when he volunteers New Amsterdam to take over for a short-staffed neighbouring hospital. Frome has a crisis of conscience about the funding for a hospital garden. An eager resident learns a secret about Bloom.
Max is forced to face the heartbreaking consequences of one of his policies; Bloom comes to a startling realisation about Iggy.
Max and Helen adjust to sharing their lives and their problems, including the challenge of Helen's mother; Bloom and Reynolds treat a family after their horrific car accident lands them in the ED; Iggy and Trevor reach a new understanding.
Max faces the pressure of his first fundraising gala at the hospital. Frome struggles to break difficult news to his daughter. Bloom and Reynolds deal with the fallout of their argument. Kapoor and Sharpe work to help a sick father and son.
Despite his struggles with treatment, Max continues to try and solve the many problems within the hospital. Meanwhile, Reynolds makes the bold decision to do an expensive surgery to pin-point an elusive diagnosis.