Chris tries to convince Reagan to have another baby. Meanwhile, Ava ends up disappointed when she joins her idol Yvonne's mentorship program.
April returns to work and learns there have been major changes at the paper during her absence. Sara reaches out to Natalie's mother, and Brenna eagerly awaits Greer's return to school.
April blows off work to spend time with members of her support group. A school trip to Miami offers Brenna the opportunity to meet Natalie.
April becomes overwhelmed as she tries to balance home and career responsibilities, Leo has suspicions about April's motives, and Brenna forms a surprising bond with a popular girl at school.
April's resolve to battle her situation wanes as her chemotherapy treatments begin to take a toll. Dominic returns to find that April has changed.