Betty loses a book, which is the complete new edition of the magazine and contains un-retouched photos of a popular actress. She has to find the book before the photos get out to the rest of the press.
A series of strangulations leads the team to look for a killer who keeps mementos of his victims and Rossi's favourite bar is in danger of closing.
There is a battle of wits between House and the attending physician who is in charge of his detox programme at Mayfield Psychiatric Hospital. House starts to lose out, and so resorts to blackmail in attempt to gain the upper hand.
A broken-hearted Spike returns to Sunnydale ready to take revenge on those he blames for his troubles, especially Angel.
The healing process gets underway as House accepts that he needs help. Can the troubled doc diagnose his demons and confront them without his Vicodin shield?
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