The team travel to Seattle to determine whether a serial bombing of centres of automated technology is being conducted by a protest group or an individual with a different agenda altogether.
In an episode directed by and guest-starring Peter Weller, the team takes on the case of Dr. Peter Treiber (guest star Jamie Elman), a pathologist at Princeton-Plainsboro Teaching Hospital who knows too much about the hospital staff to trust any of the physicians. The only person he does respect is House, who has mysteriously gone missing. With House in absentia, the team has to figure out how to treat Treiber while making him believe that House is calling all the shots.
Larry is obsessed with a book about freaks, a drunk limo driver creates trouble for Larry and John McEnroe; also, the Davids, the Greenes, Ted Danson, and Mary Steenburgen plan to be all buried together.
The team is involved in an international incident as they investigate the murder of an American petty officer whose body was found aboard a British ship.
Jane tries to find a way to get Maura to meet her biological mother; Angela gets involved in a political campaign; a nun from Jane and Frankie Jr.'s past returns.
