The bodies of two missing persons are found in a car trunk, and the BAU suspects that an interstate human trafficking ring is at work. Hotch also warns the team of possible changes.
After a series of suspicious murders occur, Prentiss suspects her old Interpol nemesis, making her fear for the safety of her BAU team as he closes in on her.
Nicky, Rebecca and Miguel go on a road trip.
A minor nose-bleed sends a panic-stricken Monk scurrying frantically to the nearest hospital, where he falls foul of a murderous medical whose outstanding surgical skills are matched only by his sheer homicidal ruthlessness.
A teenage girl goes missing from a mental hospital. Jack and the team's investigation uncovers conflicting opinions of her mental state and throws up questions about her mother's death.