Addison returns to Seattle Grace to perform a procedure on Mark's pregnant daughter; Cristina is assigned the lead on a complicated surgery.
While Jane searches for Lorelei's connection to Red John, the CBI team works with the FBI to investigate the murder of a hotel employee.
Tony is accused of murdering a woman whose body was found at Quantico and the team must prove his innocence. All the available evidence suggests that Tony is guilty, but the team works to set their agent and friend free.
Coulson and his team race against Hydra to find a man with the ability to freeze objects, and Simmons finds herself caught in the crossfire.
Raylan (Timothy Olyphant) and Boyd (Walton Goggins) collide while hunting for Dewey Crowe (Damon Herriman).