Ten years after the animals have been cured, a new threat rises in the form of `the hybrids', an army of unstoppable lab-made creatures focused on destroying mankind.
The team comes together on the island of Pangaea to put the final pieces of the cure in place.
Logan and Jackson find a link between hybrid attacks, Mitch is questioned by a woman who claims to be Clementine, and a new development in Abraham's research puts his family in danger.
Daniela and Abraham think about making a deal with Reiden Global, and Clementine and Jamie perform a dangerous surgery on Mitch.
The team sets out on a rescue mission for Abe and Dariela's son, Isaac. Mitch and Jamie travel to California and cross paths with a familiar face from their past.