Ted and Robin are surprised to bump into Barney when they volunteer at a homeless refuge during Thanksgiving. Lily's nerves are tested when she goes for Thanksgiving dinner at her future in-laws' house.
The Behavioural Analysis Unit adjusts to life after Gideon as they profile a psychiatrist who appears to be using his patients' records to realise their worst fears.
Susan goes to the therapist and realises she must choose between Ian and Mike, and Travers is having a birthday party which only spells trouble for Mrs McCluskey.
Lynette tries to change the uniforms at the pizzeria, Susan meets Ian's parents, Edie's romance is on the rocks, and Victor gives Gabrielle a dress as a gift.
A Cuban man and his wife make the risky journey to the US by boat to seek House's help in treating the woman's mysterious condition. Elsewhere, the team faces a major shake-up as Foreman prepares to leave and House comes to a shocking decision.