John Cappon

When a family arrives at Seattle Grace Hospital after a serious car accident, Alex learns that their injuries are only the beginning of their problems. Meanwhile, as Dr. Webber recovers from brain surgery, it seems that his wife (guest starring Loretta Devine as Mrs. Webber) has some concerns about the state of their marriage.

A young boy needs a heart transplant but doesn't seem to want it, and his treatment causes Burke and Yang to have philosophical differences. Meanwhile, when the interns rally to help Alex prepare to re-take his exam, Meredith has to remind Izzie of the true spirit of the Christmas holiday; and despite a reconciliation with his wife, Derek isn't in a festive mood.

Beginning February 8, “Grey’s Anatomy” enters a three-episode story arc that will challenge the interns of Seattle Grace -- and "Grey’s" fans as well -- like never before. Elizabeth Reaser (Independent Spirit Award nominee for "Sweet Land") guest stars as a patient over multiple episodes.

Meredith, Cristina, Izzie and Alex spend their first day as residents with their own interns, including George, repeating his internship after failing his exams, and Meredith's half-sister. Cristina searches for Burke, who is nowhere to be found and Richard resumes his position as chief of surgery.

With his marriage in trouble, the chief turns to his fellow male surgeons for a "gentleman's evening." Cristina and Izzie heatedly compete for the same surgeries. The doctors treat two injured finalists from a promotional competition.