With the surprising emergence of Ghost Rider, Coulson and the team attempt to stop Aida from ending the world.
As Daisy and Simmons struggle to discover an escape route to the real world, the identity of the Inhuman leader of the Resistance is revealed.
The clock is now ticking for Daisy and Simmons to get the team out of the Framework, but not everyone is ready and willing to leave.
The truth behind Fitz's turn is revealed, and it could bring down all of SHIELD. Turning on HYDRA, May sneaks a Terrigen crystal to Johnson, so she can gain her inhuman abilities within the Framework.
Daisy finds herself teaming up with an unlikely partner. Meanwhile, Aida is preparing to put her endgame into effect.