When a new inhuman is discovered, Coulson and the team have an encounter with another organisation seeking powered people. Fitz goes to extreme measures to determine how to get Simmons back.
In the aftermath of his trip to Maveth, Coulson is more determined than ever to get to Gideon Malick and put an end to Hydra once and for all. Daisy and the team encounter more Inhumans who have powers that they've never seen before.
A battle between Hydra and S.H.I.E.L.D. will change Coulson's world; Fitz and Coulson take a huge risk.
Ward's determined campaign for revenge brings the S.H.I.E.L.D. team to their knees, while Coulson proves he will do anything to settle the score.
As Daisy and the team try to protect inhumans, a shocking truth is revealed about S.H.I.E.L.D.'s biggest enemy. With Fitz's help, Simmons recovers information that could get them back through the portal.
