House uncovers a startling secret when he treats a teenage supermodel with a heroin addiction. Meanwhile, Wilson hopes the increased pain in House's leg is an indication that his nerves are regenerating.
On Devon's last day as an intern, he and Conrad are faced with a moral dilemma over a suicidal patient who is in need of a liver transplant. Adaku goes into early labour, causing a strain on her heart.
A former patient files a malpractice lawsuit against Conrad. Meanwhile, the doctors perform a risky brain surgery.
At the Democratic Party National Convention, the race to become the presidential nominee has narrowed to three candidates, Russell, Hoynes and Santos.
The Midwestern state of Iowa is the location for the first presidential debate among the candidates while Josh struggles to understand how he can guide Santos in the race.