Meredith tries to save the life of her father, who comes to the hospital with a failed liver; Izzie empathizes with a patient riddled with tumors.
The BAU team head to rural Oklahoma as women are being found murdered and robbed of one of their five senses. Meanwhile, JJ and Prentiss get the cold shoulder from Reid.
Cal Lightman and his team assist federal law enforcement in the specialist field of lie detection. Lightman turns his talents to solving a teacher's murder.
The daughter of a federal judge is murdered and investigation is carried out at the girl's high school. The Lightman Group also investigate the case of a NASA test pilot accused of intentionally crashing aircraft of multimillion dollar value.
A gang leader who claims to have been rehabilitated is questioned by Cal and Ria. Elsewhere, Gillian and Eli investigate the death of a firefighter who was killed in action.