Callie makes a decision about her relationship; the doctors receive devastating news.
Derek and Meredith adjust to life at home with their newborn; Arizona tries to repair her marriage; Jackson and Owen clash over financial issues.
Cristina enlists Meredith to help her prepare an acceptance speech for her possible Harper Avery win and while Owen offers to attend the ceremony with her, she insists on going alone. Meanwhile, Derek feels overwhelmed between his responsibilities at home and at the hospital. April and Jackson come to a disagreement on children and religion, and Callie and Arizona try to reconnect in their marriage.
The doctors are exposed to flu-infected patients; Derek prepares to give a speech; a new doctor gives Alex a glimpse into an alternative medical practice.
Upon realizing that Owen and Amelia have been seeing each other behind her back, Meredith comes down hard on her sister-in-law causing Amelia to rethink things. Meanwhile, Catherine springs into action when a man is brought into the hospital after his wife seeks revenge on his cheatings ways.
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