The doctors' lives are at risk after a dangerous patient escapes the hospital room, and Alex must make a difficult decision regarding Jo.
Richard, Jackson, April and Catherine tackle a tough trauma case intensified by hospital politics. Amelia finally faces her feelings about Owen. Meredith gets caught between Nathan and Alex.
The residents are caught in a conflict between attending physicians. April has a challenging first day in her new role at the hospital.
The doctors of Grey Sloan encounter a difficult case involving a dangerous patient. Meanwhile, Owen receives life-changing news.
Believing he is going to jail tomorrow, Alex makes a big decision about his future. While the hospital is overrun with victims of a building collapse, Richard demands answers from Bailey about Eliza's presence at Grey Sloan.