As Elizabeth heads to Rome for the G20 Conference, Henry is sent to Israel to intercept a doomsday cult's bio-weapon before it can be deployed.
Reese is captured by a former acquaintance planning a massive and potentially deadly act of cyber-warfare.
When rebel groups threaten Elizabeth's Somalian food relief programme, she reluctantly considers turning to a Russian arms dealer for help.
Elizabeth works to reunite a pair of star-crossed lovers whose union is at the heart of a Colombian peace deal after years of civil war.