The shooting death of an Air Force officer in an Iowa corn field leads Solo and Kuryakin to find a top-secret missile site.
Solo and Illya enlist a the aid of murdered scientist's daughter (Jill Ireland) in thwarting the plans of a woman (Anne Francis) armed with a secret fear gas.
An enemy agent (Carroll O'Connor) has been kidnapping potential world leaders, then brainwashing them to be loyal to THRUSH.
Solo must prevent a war by learning who is responsible for launching fungus-spraying missiles that are destroying Russia's grain crop.