Lexie watches Zola as Meredith and Derek try to have a night to themselves for Valentine's Day; Callie surprises Arizona with a romantic evening; Ben tries to prove that he knows Bailey better than she thinks.
In Providence, a serial killer apparently murdered three people at random. The perpetrator has no specific victim type, but always strikes in crowded places and uses a knife as a murder weapon.
A year has passed since House (Hugh Laurie) crashed his car into Cuddy's (Lisa Edelstein) home, and we find House spending time behind bars at the East New Jersey Correctional Facility under the close watch of the prison warden (guest star Michael Paré). When an antagonistic prison gang leader makes a serious threat, House solicits the help of a fellow inmate (guest star Jaleel White), but when another inmate's unusual medical symptoms spark his curiosity, House must come up with creative ways to treat the patient while navigating prison rules. House meets Dr. Jessica Adams (Odette Annable), a young, intelligent and bright-eyed clinic doctor, but when they are faced with a controversial opportunity to diagnose the patient's life-threatening illness, Adams is confronted with a choice to trust House and put her career on the line or play by the book.
Hank's increasing volatility forces a confrontation with Jesse and trouble at work. Skyler pressures Walt to make a deal. Gus' actions have severe consequences.
When Mike realises he forgot to make dinner reservations for Valentine's Day with Molly, he gloms onto Carl's elaborate plans with his girlfriend Christina.
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