The Seattle Grace staff continue to mourn George's death; George's mother arrives but is unsure of what to do with his organs.
Meredith tries to save the life of her father, who comes to the hospital with a failed liver; Izzie empathizes with a patient riddled with tumors.
A group of college students are rushed to Seattle Grace following a serious car crash on their way to the graduation ceremonies; Izzie continues feeling similar symptoms.
Meredith feels left out when Derek breaks ground on his clinical trial; Bailey's new idea does not go over well with the chief; Callie irritates her new obstetrician (Rachel Taylor).
A cataclysmic event leaves the doctors shaken; Callie, on the verge of a life-changing moment, starts imagining about the hospital and her friends.
