Richard tries to get Adele into Derek and Meredith's Alzheimer's trial; Arizona and Mark try to plan a baby shower for Callie.
House and Cuddy tackle a suspected meningitis outbreak on a plane. Back at the hospital, Wilson and the team treat a woman suffering mysterious seizures.
As part of the hospital's international humanitarian programme, the team takes on the case of a boy from the Congo with congenital heart anomalies.
Everyone is a suspect when a body is found murdered at a popular nightclub known as “The Lab.” In an unusual twist of storytelling, Brennan, Booth and the Jeffersonian team take on various roles outside their normal duties, including serving as the nightclub staff as well as local law enforcement. A slew of special guest stars, including Max Keenan (guest star O’Neal), Jared Booth (guest star Fehr) and the members of Mötley Crüe, pay a visit.
When a corpse is found at a landfill, dyed in a blue substance, intern Arastoo Vaziri (guest star Pej Vahdat) discovers a method that helps eliminate postmortem damages to the corpse, which leads the team back to a hair salon where the victim worked. Meanwhile Bones is feeling uncomfortable in her post-baby body, so Booth decides to do something special to boost her self-confidence.