When Gloria hires a too-good-to-be-true male nanny, Jay and Manny are pretty much dead set against it. Frank is in town and feeling a bit lonely recently, so Phil and Jay take him out to help get his groove back. And, Mitch and Cam commission Pepper to plan their dream wedding, but Pepper might be dreaming a little too big.
Richard's 10,000th surgery is a liver transplant for two sisters; Derek and Lexie take on a case that had been declared inoperable; Teddy and Cristina try to swipe a case from Alex and Dr. McQueen; Meredith tries to choose a specialty.
Gabrielle and Victor face a crisis as a picture of them sharing a passionate moment in an elevator is used to blackmail them. Elsewhere, Edie gets into a fight with one of the ladies, while another Wisteria Lane resident ends up in hospital.
Walter, Cabe and Happy are on board a top-secret submarine when an explosion sends it to the bottom of the ocean. With limited oxygen and a self-destruct function that is about to activate, can they make it out alive?
The members of the team go undercover on a movie set in Kazakhstan, hoping to disable a Soviet-era nuclear missile being sold by terrorists.
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