Richard Jenik

The day has arrived for Phil and Claire to drop Haley off at college, which is a difficult moment for any parent, but it's made worse when they manage to really embarrass Haley. Meanwhile, Manny forces Jay and Gloria to take a baby class... they humor him and go, but end up being a bit of a disruption; and Mitch and Cam drop Lily off for the first day of kindergarten, but when she gets into a tussle with another little boy, they end up having a meeting with the boy's confrontational lesbian parents.

A young boy needs a heart transplant but doesn't seem to want it, and his treatment causes Burke and Yang to have philosophical differences. Meanwhile, when the interns rally to help Alex prepare to re-take his exam, Meredith has to remind Izzie of the true spirit of the Christmas holiday; and despite a reconciliation with his wife, Derek isn't in a festive mood.

Gabrielle and Victor face a crisis as a picture of them sharing a passionate moment in an elevator is used to blackmail them. Elsewhere, Edie gets into a fight with one of the ladies, while another Wisteria Lane resident ends up in hospital.

A photograph of Tim (Tim Allen) and his new female mechanic (guest star Jenny McCarthy) puts a damper on Jill (Patricia Richardson) and Tim's wedding anniversary.

The team investigates if 15-year-old whiz kid Ryan Wallace is missing of his own accord in order to execute his elaborate plan to bomb his high school. The agents learn that the missing student is an unpopular worrier who has obsessed about safety issues since his father's fatal mugging. They initially surmise that Ryan's disappearance may have something to do with the school bullies who picked a fight with him.