A group of college students are rushed to Seattle Grace following a serious car crash on their way to the graduation ceremonies; Izzie continues feeling similar symptoms.
Izzie returns to work while the Seattle Grace residents fear possible layoffs; Bailey and Alex's difficult case is further complicated by her schizophrenic son.
With solo surgeries for the residents pending, the interns and residents scramble for practice and a way to prove themselves.
As Adele's condition deteriorates, Richard considers making a change; an explosion at a coffee shop results in a busy ER; Callie helps Meredith study; Lexie helps Alex and Arizona care for an intern's premature baby.
Bailey continues to shut everyone out; Owen worries that Ethan could end up in foster care; a new craniofacial specialist comes to the hospital to work on a young patient; a magician's assistant needs medical attention after a trick goes awry.